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However, a major pharmacokinetic limitation is the rapid absorption of butyrate in the upper gastrointestinal tract, primarily the duodenum, resulting in minimal delivery to the colon when administered in conventional formulations
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For these groups, supplementation fills a real gap
For the primary outcome (CRP), funnel plots comparing GLP-1 RAs to placebo and to other oral antidiabetic drugs (OADs) showed relatively symmetrical distributions, suggesting a low risk of significant publication bias ( Figures 2 , 3 )
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